Anticoagulated patients exhibit intact endogenous thrombin potential using ST Genesia unlike the Calibrated Automated Thrombogram
نویسندگان
چکیده
منابع مشابه
Whole-blood thrombin generation monitored with a calibrated automated thrombogram-based assay.
BACKGROUND The calibrated automated thrombogram (CAT) assay in plasma is a versatile tool to investigate patients with hypo- or hypercoagulable phenotypes. The objective was to make this method applicable for whole blood measurements. METHODS Thin-layer technology and the use of a rhodamine 110-based thrombin substrate appear to be essential for a reliable thrombin generation (TG) assay in wh...
متن کاملThrombin generation increasing with age and decreasing with use of heparin indicated by calibrated automated thrombogram conducted in Chinese.
OBJECTIVE Calibrated Automated Thrombogram(CAT) is a test to monitor the generation of thrombin. It can be described by four parameters: lag time, peak thrombin, endogenous thrombin potential (ETP) and time to peak (ttPeak). This study aims to determine the normal ranges of CAT parameters in Chinese, and evaluate whether thrombin generation is correlated with the concentration of heparin/low mo...
متن کاملCharacterization of thrombin generation potential of leukemic and solid tumor cells by the calibrated automated thrombography
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متن کاملCharacterization of the thrombin generation potential of leukemic and solid tumor cells by calibrated automated thrombography.
BACKGROUND Thrombin, the final enzyme of blood coagulation, is a multifunctional serine protease also involved in the progression of cancer. Tumor cells may activate blood coagulation proteases through the expression of procoagulant activities. However, specific information about the thrombin generation potential of malignant tissues is lacking. In this study we applied a single global coagulat...
متن کاملEx vivo coagulation test on tissue factor-expressing cells with a calibrated automated thrombogram.
A calibrated automated thrombogram is not affected by the turbidity of platelet and cell preparations because the measurement is based on fluorescence. To examine conditions that mimic the physiological state, we investigated thrombograms that show thrombin generation on tissue factor (TF)-bearing cells. An increase in the number of J82 cells did not affect the endogenous thrombin potential (ET...
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ژورنال
عنوان ژورنال: Research and Practice in Thrombosis and Haemostasis
سال: 2021
ISSN: 2475-0379,2475-0379
DOI: 10.1002/rth2.12497